Hyaluronic Acid

What is Hyaluronic acid?

Hyaluronic acid is the essential natural, physiological constituent of intact, healthy tissue. In the oral cavity it is a major constituent of the extracellular connective matrix of the periodontal tissues, the main component of intercellular ground substance and capillary walls. It is present in healthy tissues in the form of a polymer with high molecular weight. This molecule is highly active in terms of its biological profile and is present in particularly high concentrations in the gingivae and periodontal ligament.

Clinical Results

Hyaluronic Acid has been widely used in dentistry for well over 10 years, with dozens of clinical trials demonstrating its efficacy in the management of a broad range of intra-oral inflammatory conditions. Below are the results of a couple of trials involving some of the most common conditions, more trial results are available on request:

Inflammation & Bleeding

0.2% Hyaluronic Acid Gel significantly reduces inflammation and bleeding over 3-6 days compared to placebo3

Oral Ulcers

The efficacy of 0.2% Hyaluronic Acid Gel on recurring oral ulcers4


0.2% Hyaluronic acid significantly improves Approximal Plaque Index (API), Turesky index and Papillary Bleeding Index (PBI) scores for patients with plaque-induced gingivitis5

Reduction in signs of Gingivitis after scaling and scaling + 0.2% Hyaluronic acid5


  1. Weigel PH, Fuller GM, Le-Boeuf RD (1986) A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing. Journal of Theoretical Biology; 119 (2):219-234.
  2. Sakasi T and Watanabe C (1995). Stimulation of osteoinduction in bone wound healing by high-molecular hyaluronic acid: Bone; 16:9-15.
  3. Pistorius A, Martin M, Willershausen B et al.(2005) The clinical application of hyaluronic acid in gingivitis therapy. Quintessence International; 36:531-538.
  4. Lee JH, Jung JY, Bang D. (2008) The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet’s disease. Journal of the European academy of dermatology and venereology; 22(5):590-595.
  5. Sapna N, Vandana KL. (2011) Evaluation of hyaluronan gel (Gengigel) as a topical applicant in the treatment of gingivitis. Journal of Investigative and Clinical Dentistry; 2(3):162-170.